Thimerosal blocks stimulated but not basal release of endothelium-derived relaxing factor (EDRF) in dog isolated coronary artery
نویسندگان
چکیده
منابع مشابه
Endothelium-derived relaxing factor and coronary vasospasm.
The endothelium releases the powerful vasodilator and antiaggregatory substance, EDRF, both under basal conditions and upon stimulation by a wide variety of agents. Endothelial injury or dysfunction may play an important role in the spasmogenicity of the coronary artery, although other possible alterations related to atherosclerosis should also be considered. Among the possible stimuli, aggrega...
متن کاملEndothelium-Derived Relaxing Factor
The vascular effects of endothelin-1 (ET) in humans were investigated by brachial artery infusions of ET into 25 healthy volunteers. Forearm blood flow increased from a mean±SD value of 2.3± 1.5 to 2.5± 1.5 ml/min/100 ml forearm tissue (n=25, p<0.05) in response to low dose (0.5 ng/min/100 ml forearm tissue) ET infusion and decreased to 1.78±1.3 and 1.1±0.9 ml/min/100 ml forearm tissue (p<0.001...
متن کاملEnhanced release of endothelium-derived relaxing factor in mineralocorticoid hypertension.
Ring segments of superior mesenteric arteries studied in vitro were used to determine the role of the vascular endothelium in regulating vascular contractile and relaxant sensitivity in deoxycorticosterone acetate (DOCA)-salt hypertension. Wistar rats were given DOCA (20 mg/kg s.c. twice per week) and 1% NaCl drinking water for 5 weeks. In ring segments containing endothelium, there was a decre...
متن کاملShear Stress Determine the Basal Release of Endothelium-Derived Relaxing Factor in the Intact Rabbit Coronary Vascular Bed
We investigated the mechanisms that are responsible for the basal release of endotheliumderived relaxing factor (EDRF), which is likely to be identical with nitric oxide, in the intact coronary circulation. The increase in cGMP content of platelets passing through the coronary bed of the isolated rabbit heart was used as an index of EDRF release. Platelet cGMP content after passage through the ...
متن کاملRelease of endothelium-derived relaxing factor from human umbilical vessels.
The ability of human umbilical endothelial cells to release relaxing substance(s) in response to different agonists was investigated. Endothelium-denuded aortic rings of rats were used for the bioassay and tension recording. After precontraction, this preparation showed no response to histamine, acetylcholine, A 23187, or adenosine triphosphate while serotonin elicited further contraction. Supe...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 1992
ISSN: 0007-1188
DOI: 10.1111/j.1476-5381.1992.tb12784.x